BIOGRAPHY KRISANA KRAISINTU, PH.D
Dr. Krisana Kraisintu is a Pharmaceutical Consultant in the local production and increased access to life-saving medicines in Africa, in particular, in the domains of Malaria and HIV/AIDS-related drug production. She was formerly Director of Research and Development Institute, Government Pharmaceutical Organization (GPO), Ministry of Public Health, Thailand. Between 2002 – 2007 Dr. Kraisintu worked as a Pharmaceutical Consultant for action medeor, a German Aid organization which is a non-profit organization dealing with local production and distribution of medicines in Africa. Currently, Dr. Kraisintu is the Honorary Dean of Faculty of Oriental Medicines, Rangsit University and a visiting Professor at the Faculty of Pharmaceutical Sciences, Ubon Rajathanee University, Thailand. She is also a visiting Professor of Oriental Medicines at Harbin Institute of Technology, China. Dr. Kraisintu received her Bachelor degree in Pharmacy from Chiengmai University, Thailand in 1975, M.Sc. in Pharmaceutical Analysis from Strathclyde University, U.K. in 1978 and Ph.D. in Pharmaceutical Chemistry from University of Bath, U.K. in 1981. For the past 28 years, she has worked in the pharmaceutical industry in various roles of quality assurance, manufacturing, research and development and business development for the discovery, development and commercialization of chemical and natural pharmaceutical products.
PHARMACEUTICAL WORK EXPERIENCE IN THAILAND
From 1992 to 2002, Dr. Kraisintu worked on the formulation development and bioequivalence studies of HIV/AIDS -related drugs. Her unwavering conviction of AIDS as a social issue and her dedication to increase access to HIV/AIDS treatment in Thailand resulted in the successful research and generic manufacturing of Zidovudine (AZT) to prevent mother to child transmission in 1992. Her achievement raised the pharmaceutical and health profile of Thailand as the first developing country to manufacture generic HIV/AIDS drugs. In 1998 Dr. Kraisintu developed one of the first generic ARV fixed-dose combinations, which has now been chosen by WHO as the first regimen treatment for HIV/AIDS patients in poor countries. In Thailand, this drug (GPO-VIR) is used in the national HIV/AIDS treatment programme, making it free of charge for 100,000 patients. It is made available due to the fact that Dr. Kraisintu’s formulation drastically reduces the prices of the finished products from the original prices. In sum, the cost of HIV/AIDS treatment in Thailand for a patient is lower from 570 – 850 US Dollars to 35 US Dollars per person per month. Dr. Kraisintu further developed 5 other types of antiretroviral drugs for the patients. Her invention has enabled GPO to export antiretroviral drugs to neighbouring countries of Thailand such as Burma, Lao, Cambaodia and Vietnam where poor patients are in great need of high quality and affordable drugs. During her tenure as Director of Research and Development Institute of GPO (from 1987 to 2002), Dr. Kraisintu developed 64 herbal basedmedicinal products ranging from medicines to supplementary food and cosmetics in addition to various medicines for the treatment of diabetes, high blood pressure, high level of cholesterol and specific drugs for children. As a consequence, Thai patients are able to afford high quality medicines and enjoy a long and healthy life.
Dr. Kraisintu’s love of herbal medicines and her family heritage in medicinal and herbal treatment contribute greatly to her pursuit of promoting the widespread use of Thai traditional herbal medicines in modern forms, i.e. tablet, capsule, gel, cream and dissolvable powder, for poor people in rural Thailand. Accordingly, Dr. Kraisintu and the Faculty of Pharmaceutical Sciences, Ubon Rajathanee University, Thailand, set up a production unit to manufacture 4 traditional herbal products from 78 medicinal plants in January 2009. These products are very popular and widely used by local people in the Northeastern provinces of Thailand to treat common symptoms and promote their health. The production unit at Ubon Rajathanee University will also act as a training centre for industrial pharmaceutical training for Thai pharmacy students as well as for personnel from African countries.
PHARMACEUTICAL WORK EXPERIENCE IN AFRICA AND CHINA
Since 2002, Dr. Kraisintu has dedicated her time, energy and efforts for humanitarian purpose of assisting poor African countries to establish local pharmaceutical production. Her goal is two-fold; first utilizing her expertise and experience in guiding these countries to build high standard pharmaceutical factories and second to transfer the technology in the production and quality control of essential medicines such as antimalarial and antiretroviral drugs on an industrial scale to local health and pharmaceutical personnel. The ultimate result is self-reliance and sustainable access to lifesaving medicines for the patients. From 2002 to 2005 Dr. Kraisintu provided technical assistance and know-how to Pharmakina in Bukavu, Democratic Republic of Congo (DRC) in the setting up of an ARV plant and the manufacturing of ARV fixed-dose combination known as AFRI-VIR. At the same time, she was responsible for the construction of an ARV plant and an antimalarial drug unit at Tanzania Pharmaceutical Industry (TPI) in Arusha. Subsequently, TPI was able to manufacture artemisinin-based anti-malarial drugs for both adults and paediatric patients in 2003 and ARV fixed-dose combination known as TT-VIR in October 2005.
Dr. Kraisintu continues to be active in pharmaceutical production of essential drugs in Africa. From 2006 to 2008, Dr. Kraisintu was invited by the Ministry of Foreign Affairs of Thailand to spearhead the humanitarian projects on the transfer of technology in the local production of antimalarial and antiretroviral drugs in West African countries, namely Senegal, Gambia, Burkina Faso, Mali and Gabon and in East African countries, namely Tanzania, Ethiopia and Uganda, in Burundi and Zambia. This close collaboration has resulted in the capacity building and competence of the health personnel in the concerned countries, who are now able to manufacture antimalarial drugs for their respective needs. In particular, the personnel of l’Usine Malienne de Produits Pharmaceutiques (U.M.P.P.), the public factory in Mali has mastered the techniques and undergone intensive training (both production and quality control) to produce co-blistered of artesunate and amodiaquine tablets as well as fixed-dose combination of artesunate and amodiaquine in one single tablet, the first African country to accomplish this spectacular pharmaceutical achievement. In September 2008 Dr. Kraisintu traveled to Saint Camillus Hospital in Karungu, Kenya in response to the invitation of Father Emilio Balliana, Director of the hospital to train the hospital personnel in the production of artesunate suppositories. From 2008 to 2009, Dr. Kraisintu initiated 2 projects within the framework of bilateral and technical cooperation between Thailand and Burundi to foster capacity-building and local production of antimalarial drugs in the Republic of Burundi. Her endeavour has led to the setting up of a pharmaceutical production unit in Bujumbura with capacity of manufacturing artesunate suppositories and artesunate and amodiaquine tablets for both children and adults. In 2009 Dr. Kraisintu established a specialized unit for research and development of herbal medicines and a manufacturing facility at Harbin Institute of Technology in China.
AWARDS AND ACHIEVEMENTS
– A Gold Medal at Eureka 50th World Exhibition of Innovation, Research and New Technology, Brussel, Belgium, 2001.
– “Global Scientific Award 2004” by The Letten Foundation as a recognition of Dr. Kraisintu’s outstanding scientific contribution in the field of HIV/AIDS.
– Honorary Degree of Doctor of Science from Mount Holyoke College, USA, May 2005.
– Reminders Day AIDS Award 2005 (ReD Awards) in Berlin, Germany, August 2005.
– Honorary Degree of Doctor of Pharmacy from Chiengmai University, Thailand in January 2006.
– Honorary Degree of Doctor of Science from Strathclyde University, U.K., June 2006
– “2007 speaker for the Chancellor’s Distinguished Lectureship Series”, Louisiana State University’s premier lecture series, Louisiana State University, USA, April 2007.
– “Asian of the Year 2007” selected by Reader’s Digest Magazine, January 2008. Her profile was published in the magazine’s different languages editions in 26 countries around the world.
– The Prime Minister’s Office of Thailand has awarded Dr. Kraisintu “an outstanding individual of Thailand in the field of Social Development for the year 2008”.
– “Citizen Hero Award” by Sanya Thammasak Institute for Democracy, University of Thammasart, Thailand, March 2009.
– “Honorary Pharmacist” by Hospital Pharmacists’ Society of Thailand, May 2009.
– Honorary Degree of Doctor of Science from University of Bath, U.K., July 2009.
Dr. Kraisintu has written a book on “Quality Assurance and Control of Pharmaceutical Chemistry” as well as more than 100 articles on different themes and aspects of pharmaceutical industry. They include
– Infrastructure needs for production and quality control of pharmaceuticals.
– Status of Medicinal and Aromatic Plants in Cambodia, Laos, Philippines, Thailand and Vietnam.
– Industrialization of Medicinal and Aromatic Plants.
– Generic Production of HIV/AIDS – related Drugs in Thailand.
– Increasing Access Towards a Sustainable HIV/AIDS treatment.
– The Importance of Generic Drugs Applicability of ICH guidelines for artemisinin-based antimalarial production in Africa: Benefits or Barriers. The stories of her life, work and experience have been published and televised in different Thai and foreign media including
– A Theatre play “Cocktail” by Swine Palace and the Louisiana State University (LSU) Performing Arts, on Dr. Kraisintu’s life and her steadfastness in overcoming all challenges to bring about high quality and affordable locally produced antiretroviral drugs in Thailand and in the Democratic Republic of Congo in April 2007. The play’s book was published by Silkworm Books in February 2009. In addition, a Thai play on the book will be staged at the National Cultural Theatre of Bangkok in August 2009.
– French TV5 produced a documentary entitled “Labo: La Loi du Profit” about Dr. Kraisintu’s dedication and tireless work in Africa. It was televised in France, Canada and the Francophone countries in Africa in 2006.
– A German television channel filmed a documentary about Dr. Kraisintu’s work in Tanzania entitled “A right to live” and aired it in Germany and France on “World’s AIDS Day” (1 December 2006).
– To date, Dr. Kraisintu has documented her journeys to save millions of life in Africa and her fond memories of the African people in 3 published books in the Thai language entitled “Gypsy Pharmacist” on the Democratic Republic of Congo, Tanzania and West African countries respectively.
– A Thai book on the “Legend of Thai Traditional Herbal Medicines”, co-written and edited by Dr. Krisana Kraisintu, 2009.