Dr. Jawad Alzeer

|Dr. Jawad Alzeer
Dr. Jawad Alzeer 2017-10-19T08:00:08+00:00

Project Description

CURRICULUM VITAE

 

PERSONAL DETAIL:

Name: Dr. Jawad Alzeer
Citizenship: Swiss
Marital Status: Married
E-mail: zeerj@yahoo.com

 

EDUCATION: COMPETENCE IN ORGANIC CHEMISTRY, MEDICINAL CHEMISTRY, NUCLEIC ACID CHEMISTRY, AND NATURAL PRODUCT

 

1990-1995: Ph.D. in Organic Chemistry Swiss Federal Institute of Technology (ETH), Zurich, Switzerland

1987-1989: M.Sc. in Organic Chemistry University of Karachi, Pakistan
1983-1987: B. Sc. (Hons) in Chemistry, Physiology and Microbiology as minor subjects University of Karachi, Pakistan
1985-1986: Maths Certificate in Mathematics University of Karachi, Pakistan

 

DOCTORAL DISSERTATION

 

Title: Towards oligosaccharide analogues of cellulose, ETH Zurich, 1995. Advisor: Prof. A. Vasella; Co-examiner: Prof. F. Diederich

 

PROFESSIONAL EXPERIENCE: ACADEMIC & INDUSTRIAL; TEACHING, ORGANIC SYNTHESIS, DRUG DESIGN, REFERENCE COMPOUNDS, GENE THERAPY, G-QUADRUPLEX DNA, CANCER RESEARCH, MEDICINAL PLANTS

 

January 2014-now: Director of Swiss Scientific Society for Developing Countries, Zürich, Switzerland
January 2010-Now: Head of scientific board and Senior Consultant, Halal Certification Services, Rheinfelden, Switzerland. “Audit food products that meet Halal requirements”
June 2012-now: Senior Scientist, Department of Chemistry, Zürich University, Switzerland
‘Investigate medicinal plant as potential therapy for cancer’
‘Design, synthesis and evaluation of anticancer compounds that interact with Different G-quadruplexes structures’.
September 2010-Now: Assistant Professor, Palestine Polytechnic University, Applied science department, Hebron, Palestine.
“Design and development of novel, mild and efficient extraction method for natural products”
October 2009-August 2010: Senior Scientist, Lipomed AG, Arlesheim, Switzerland
‘Design of new anti-cancer drugs, Synthesis of drug reference standards, Management of pre-clinical and clinical research, Supervising and leading staff in drug manufacture, Presenting scientific lectures, Scientific consultant’
October 2006-September 2009: Senior Research Associate, Institute of Organic Chemistry, Zürich University, Switzerland
‘Design, synthesis and evaluation of potential anticancer compounds that interact with human telomeric G-quadruplexes DNA and inhibit telomerase enzyme’
March 2001-September 2006: Research Associate, Institute of Molecular Cancer Research (IMCR), Zürich University, Switzerland
‘Development of a simple and concise approach for the synthesis of well-defined bridged interstrand cross-link DNA’
‘Design of chemical approach for targeted mutagenesis by exploiting the base excision repair pathway’
Feb 2000-Feb 2001: Assistant Professor, Palestine Polytechnic University, Hebron, Palestine
‘Teaching introductory, general chemistry, supervising chemistry laboratories, design and engineering laboratory course’
November 1998-February 2000: Postdoctoral Fellow, University of Michigan, Ann Arbor, USA
‘Synthesis of nucleoside and non-nucleoside inhibitors of human immunodeficiency virus reverse transcriptase’
March 1996-September 1998: Postdoctoral Fellow, Hoffmann La Roche, Basel, Switzerland
‘Identification and optimisation of a new antimalarial pharmacophore: phenyl -methoxyacrylates, linked to an aromatic ring via olefinic bridge, have been identified as novel, potentially inexpensive, antimalarial agents’
March 1993-December 1995: Research Fellow, Swiss Federal Institute of Technology, (ETH), Zurich, Switzerland
‘A new approach towards polysaccharide analogues: Preparation of mono- and oligomeric acetylenosaccharides up to a fully deprotected octamer’
October 1990-March 1993: Research Fellow, Institute of Organic Chemistry, Zürich University, Switzerland
‘Synthesis of Acetyleno-Oligosaccharides: Stereoselective introduction of alkynyl groups into glucose’
October 1989-October 1990: Research Fellow, H.E.J. Research Institute of Chemistry, Karachi, Pakistan
‘Synthesis of biologically active compounds from readily available carbohydrates’
April 1988-June 1989: Research Assistant, Department of Chemistry, Karachi University, Pakistan
‘Synthesis of C-disaccharides by a carbon Ferrier rearrangement’
‘Teaching general and organic chemistry’

 

HONORS: FIRST CLASS WITH DISTINCTION

 

Offered Merit Certificate from University of Karachi
Stood Fourth Position in the Faculty of Science.
Stood Second Position in the Chemistry Department
M.Sc. and B.Sc. with Distinction
Secured “A” Grade in all Chemistry Courses

 

PATENT & PUBLICATIONS:

 

1- Martin S. Seyfried, Jawad Alzeer, Nathan W. Luedtke: “Molecular Design and Synthesis of a Planar Telomestatin Analogue”. Eur. J. Org. Chem. 2015.
2- Jawad Alzeer: “Swiss Scientific Society for Developing Countries: A Concept of Relationship”. World Academy of Science, Engineering and Technology, International Science Index, Humanities and Social Sciences, 2015, 2(1), 1733
3- Zahra Aljabari, Jawad Alzeer, Rami Arafeh: Catechin detection in callus and in vitro cultures of the eastern strawberry tree, Arbutus Andrachne L., an endangered medicinal tree in Palestine, Global J Res. Med. Plants & Indigen. Med. | Volume 3, Issue 5 | May 2014 | 196–205
4- Jawad Alzeer, Bala Vummidi, Rami Arafeh, Waleed Rimawi, Hatem Saleem, Nathan Luedtke: The influence of extraction solvents on the anticancer activities of Palestinian medicinal plants, J. Med. Plant Res. 2014, Vol. 8, P. 408-415
5- Bala Vummidi, F. Noreen, Jawad Alzeer, K. Moelling Nathan Luedtke: Photodynamic agents with anti-metastatic activities, ACS Chem. Biol., 2013, 8, 1737.
6- Bala Vummidi, Jawad Alzeer, Nathan Luedtke: Fluorescent probes for G-quadruplex structures, 2013, ChemBioChem. 2013, 14 (5): 540-58.
7- Sarah. Hentschel, Jawad Alzeer, Todor. Angelov, Orlando. D. Schaerer, Nathan. W. Luedtke: Synthesis of DNA interstrand crosslinks using a photocaged nucleobase, Angew. Chemie Intl. Ed., 2012, 51, 3466. (English) Sarah. Hentschel, Jawad Alzeer, Todor. Angelov, Orlando. D. Schaerer, Nathan. W. Luedtke: Synthese von DNA-Interstrang-Crosslinks unter Verwendung einer photoaktivierbaren Nucleobase. Angewandte Chemie, 2012, 124, 14, 3523–3526. (German)
8- Jawad Alzeer, Nathan Luedtke: pH-Mediated Fluorescence and G-Quadruplex Binding of Amido Phthalocyanines, Biochemistry, 2010; 49 (20), pp 4339-4348.
9- Manikandan Paramasivam, Alexandro Membrino, Susanna Cogoi, Jawad Alzeer, Nathan W. Luedtke, and Luigi E. Xodo: “Cellular uptake and G-4 DNA promoter binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes” Chem. Commun, 2010; 46 (4): 625.
10- Jawad Alzeer, Bala Vummidi, , Phillipe J C Roth and Nathan Luedtke: “Guanidinium-Modified Phthalocyanines as High-Affinity G-Quadruplex Fluorescent Probes and Transcriptional Regulator” Angew. Chem., 2009; 48 (49): 9362. (English)
Jawad Alzeer, Dr, Balayeshwanth R Vummidi, Phillipe J C Roth, Nathan W Luedtke (2009) Guanidinium-modifizierte Phthalocyanine als Fluoreszenzso-nden mit hoherG-Quadruplex-Affinität und als Transkriptionsregulatoren Angewandte Chemie, 2009; 121: 49. 9526 (German)Jawad Alzeer, Dr, Balayeshwanth R Vummidi, Phillipe J C Roth, Nathan W Luedtke (2009) Guanidinium-modifizierte Phthalocyanine als Fluoreszenzso-nden mit hoherG-Quadruplex-Affinität und als Transkriptionsregulatoren Angewandte Chemie, 2009; 121: 49. 9526 (German)Jawad Alzeer, Dr, Balayeshwanth R Vummidi, Phillipe J C Roth, Nathan W Luedtke (2009) Guanidinium-modifizierte Phthalocyanine als Fluoreszenzso-nden mit hoherG-Quadruplex-Affinität und als Transkriptionsregulatoren Angewandte Chemie, 2009; 121: 49. 9526 (German)
11- Jawad Alzeer, Philippe Roth, and Nathan Luedtke: “An efficient two-step synthesis of metal-free phthalocyanines using a Zn (II) template” Chem. Commun, 2009; 15, 1970-1971.
12- Nathan. W. Luedtke, Jawad Alzeer, Bala Vummidi, Preparation and uses of guanidinium-modified porphyrins and phthalocyanines, 2008, European Patent Patent No. 2010028780.
13- Jawad Alzeer, Orlando Schärer: “A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrands crosslinks” Nucleic Acid Research. 2006; 34 (16); 4458-4466
14- Ludovic Gillet, Jawad Alzeer, Orlando Schärer: “Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified “ultra-mild” DNA synthesis crosslinks” Nucleic Acid Research. 2005; 33(6); 1961-1969.
15- Jawad Alzeer, Jacques Chollet, Ingrid Heinze-Krauss, Christian Hubschwerlen, Hugues Matile, and Robert Ridley “Phenyl Methoxyacrylates: A New Antimalarial Pharmacophore” J. Med. Chem. 2000; 43 (4); 560-568.
16- Jawad Alzeer, Jacques Chollet, Christian Hubschwerlen, Hugues Matile, and Robert Ridley “-Alkoxyacrylates Against Malaria” European Patent Application No. 97111607.4, PCT/EP1998/004162, 1999 (WO/1999/002150).
17- Jawad Alzeer, Raffaello Masciadri, Nadine Nock, and Guy Wassner “MOM-protected 3-Hydroxy-5-phenyl-isoxazole: Regioselective Preparation and Synthetic Application” Tetrahedron Lett., 1996, 37, 6857-6860.
18- Jawad Alzeer, and Andrea Vasella “Oligosaccharide Analogues of Polysaccharides Part 4. Synthesis of a Monosaccharide-Derived Octamer” Helv. Chem. Acta., 1995, 78, 1219-1237.
19- Jawad Alzeer, and Andrea Vasella “Oligosaccharide Analogues of Polysaccharides Part 2. Regioselective Deprotection of Monosaccharide-Derived Monomers and Dimers” Helv. Chem. Acta., 1995, a78, 177-193.
20- Jawad Alzeer, Chengzhi Cai, and Andrea Vasella “Oligosaccharide Analogues of Polysaccharides Part 1. Concept and Synthesis of Monosaccharides-Derived Monomers” Helv. Chem. Acta., 1995, 78, 242-264.
21- M. S. Shekhani, K. M. Khan, Jawad (Al) Zeer and W. Voelter “Useful Chiral Intermediates from Readily Available Carbohydrates” 200th National Meeting of the American Chemical Society, Washington, D. C., September 1990 ORGN 197.

 

MANUSCRIPTS, POSTER & BOOK CITATION

 

1- Jawad Alzeer, Balayeshwanth R. Vummidi, and Nathan W. Luedtke, “Cell-Permeable Fluorescent Probes with High Affinity for G-Quadruplex DNA and RNA” Second Second International Meeting on Quadruplex DNA April 18-21, 2009 Camberley-Brown Hotel, Louisville, KY, USA
2- Jawad Alzeer Balayeshwanth R. Vummidi, Phillipe J. C. Roth, and Nathan W. Luedtke, G-Quadruplex Fluorescent Probes as Transcriptional Regulator, 2nd Swiss-Japan Biomolecular Chemistry Symposium, 2009–SJBCS2009
3- Jawad Alzeer, Bala Vummid, Phillipe Roth, and Nathan Luedtke, “Structure-Selective Fluorescent Probes for G-Quadruplex DNA” Swiss chemical Society, fall meeting Zurich (Switzerland), 09.2008.
4- Jawad Alzeer, Orlando Schärer: “Synthesis and characterization of site-specific thymine-guanine DNA interstrand crosslinks” International roundtable on nucleosides, nucleotides and nucleic acids. 2006; XVII; PO030.
5- Jawad Alzeer, Jacques Chollet, Ingrid Heinze-Krauss, Christian Hubschwerlen, Hugues Matile, and Robert Ridley, Anne Schmitt Hoffmann: “-methoxyacrylates, anovel class of antimalarial agents” Hoffmann La Roche, B-169’710; 1999.
6- Oligonucleotide synthesis using phosphoramidite chemistry, produced by Link Technologies Ltd., UK, Section 2.1, Ultramild Deprotection, Page 66
7- Theodora W. Greene, Peter G. Wuts “Protective groups in organic chemistry” third edition, John Wiley & Sons, Inc. NJ; 1999; Protection for the hydroxyl group-benzylether; P. 83, Protection for the alkyne-CH; P. 655.
8- F. Diederich, P. J. Stang, R. R. Tykwinski “Acetylene Chemistry: Chemistry, biology, and material science” 2005; Wiley-VCH Verlag GmbH & Co. KGaA. Acetylenosaccharides, Page 196.

 

MASTER THESIS

 

1- Zahra Yasser Al-jabary, In Vitro Propagation of Arbutus andrachne L. and the Detection of Catechin, 2011.
2- Ghada M. Haroon Abu Khalaf, Capparis spinosa L. “Caper”: In Vitro Cultures and Bioassay, 2011.
3- Wala’ Manasrah, In Vitro Propagation of Crataegus aronia and secondary metabolites detection, 2012.
4- Ali Essa Abu Allan, Ziziphus spina-christi “Christ’s Thorn”: In Vitro Callus and Cell Culture, Qualitative Analysis of Secondary Metabolites and Bioassay, 2012.

 

ADDITIONAL KNOWLEDGE:

 

Languages: Arabic–fluent; English; German; Urdo.
Computing: Detailed knowledge of Word, Excel, PowerPoint, Photoshop, Beilstein & SciFinder on PC & Mac
Teaching and advising: Teaching assistant; advising Master and PhD students.

 

EXTRA ACTIVITIES: SOCIAL AND GENEROUS PERSONALITY

 

Collect unique pens, reading history books, playing basketball, combine imagination with reality